The main components of colistin sulphate.
【Properties】 white or off-white powder.
Pharmacological effects pharmacodynamics peptide antibiotic
polymyxin genus, is a basic cationic surfactants, phospholipids and
bacterial cell membrane through interaction, to penetrate the
bacterial cell membrane, destruction of the structure, thereby
causing the membrane permeability changes, resulting in bacterial
death, generating a bactericidal effect.
The product of aerobic bacteria, E. coli, Haemophilus, Klebsiella,
Pasteurella, Pseudomonas aeruginosa, Salmonella, Shigella bacteria
Gram-negative bacteria have a strong antibacterial effect on
colistin sensitive bacteria produce little resistance. Proteus and
Serratia most affected from colistin. Gram-positive bacteria are
usually not sensitive.
Pharmacokinetics oral administration is hardly absorbed, but
parenteral administration is rapidly absorbed. Drug into the body
can be quickly distributed into the heart, lungs, liver and
skeletal muscle, but not easy to enter the cerebrospinal, pleural,
articular lesions and infections. Primarily by renal excretion.
Indications for the prevention and treatment of pigs, chickens and
intestinal infections caused by Gram-negative bacteria, such as
Piglet dysentery, piglets white diarrhea, piglet paratyphoid fever,
salmonellosis, chicken E. coli disease.
Dosage in terms of the product. Mixed drink: every 1L of water,
chicken 0.2 ~ 0.6g; spices: pig feed per 1kg of 0.4 ~ 0.8g.
Adverse reactions polymyxin class when taken orally or topically
animal well tolerated, systemic application can cause renal
toxicity, neurotoxicity, and neuromuscular blocking effects,
toxicity polymyxin than polymyxin B Small .
[Note] (1) laying on the disabled.
(2) should not be used continuously for more than a week.
[Withdrawal period] pigs, chickens 7th.
[Specification] 100g: 10g (3 million Units)
【Packing】 100g / bag90 bags / box.
[Storage] shading, sealed and stored in a dry place.
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