Main component: Sterile solution mixed by ivermectin and eligible
Description: Colorless, clear liquid,a little sticky.
PharmacodynamicsIt has favorable killing effect to endoparasite and
ectoparasite especially arthropod and endoparasite. The mechanism
of action is promote Presynaptic Neuronal to releaseγaminobutyric
acidGABA,thereby open chloride channel mediated by GABA, thus open
the chloride channel mediated by GABA . also has selectivity and
high affinity to the chloride channel mediated by glutamic acid
which is nearby mediated point of GABA of the invertebrate nerves
and muscles cell. Chlorine ion current can reduce membrane
impedance of cell, result in slight depolarization of postsynaptic
cell prohibition , interfere the signal transmission between nerve
and muscle, so that the polypide become lack and paralysis, then
die or be eliminated. Consistency integrator cell and excitatory
neuron is the site of action to edlworm, while Neuromuscular
Junctions is the site of action to arthropod.
Pharmacokinetics The bioavailability is high by Subcutaneous
injection, can be distributed in majority tissue, but not easily
enter cerebrospinal fluid. Apparent volumes of distribution of
cattle, sheep, pig, dog respectively are 0.452.44.64 and 2.4l/kg.
The have long half life in majority animals. In cattle, sheep, pig,
dog are respectively 23270.5 and 2 days. Its metabolized in liver.
the method is hydroxylation in sheep and methylation in swine. It
be eliminated by excrement. less than 5% of it is eliminated by
urine in original appearance or metabolic product. For lactating
animals, even 5% of it be eliminated from galact.
Drug interaction: If used together with Carbilazine, there will
lead to severe or fatal cerebropathy.
Application: Prevent and cure nemathelminthiasis of
gastrointestinal tract, buffalo-hide rope warble fly larvina,
psoroptosis of sheep , gaile of pig and other parasitosis.
Usage and dosage: Subcutaneous injectionpro dosi, cattlesheep 0.2mg
/kg b.w.pig 0.3mg /kg b.w.
24 hours after medication, the horse may appear dropsy and pruritus
nearby medioventral line because of allergic response caused by the
dead of filariae. And the dropsy will decrease in 7-10 days, the
pruritus will relieve within 3 weeks.
When using for treat babiche larvae disease of cattle, if the
larvae died in criticality part, it will cause severe adverse
effect. If in spinal canal, will cause palsy and stagger; if in
oesophagus, will cause dribble or gaseous. If treat immediately
after the warble fly season or after migratory stage of warble fly
larval, the above problems will be avoided. Meanwhile, the
injection site will be indisposition or edema fugax, this will
decrease by injecting at different site(the dosage no more than
10ml at each site).
When treating microfilaria infect, dog may have shock response,
this maybe related to the dead microfilaria.
Poultry may die, hypnody or decrease food appetite.
1Only hypodermic injection is permitted,intramuscular injection,
intravenous injection will cause toxic reaction,the dosage of each
hypodermic injection should be limited in 10ml.
2Ivermectin Injection which contains glycerine mini-formaldehyde
and propylene glycol, only refer to cattle, sheep, pig and
reindeer,if used to other animals especially for dog and horse, it
will cause serious local reaction.
3Various dogs are safety in using it, while shepherd dog is
sensitive to it,dosage above 0.1mg/kg will lead to serious adverse
effect,should be careful in this.
4It has rank poison to prawn, fish and aquatic,package which
remaining this dug shouldnt contaminate water source.
Withdraw period: Cowsheep 35 days,pig 28 days,prohibited during