Selective Estrogen Blocker Antiestrogen Raw Powder Tamoxifen
Citrate / Nolvadex 54965-24-1For PCT Use
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Tamoxifen citrate basic info.
USE: Anti tumor drug
Molecular Formula: C26H29NO.C6H8O7
Molecular weight: 563.64
CAS NO.: 54965-24-1
MP: 140-144 ºC
Nolvadex (Tamoxifen Citrate) info.
A concern about anabolic steroid use is the resulting suppression
of natural testosterone production. During an anabolic steroid
cycle itself, this suppression is unavoidable and isn’t necessarily
a problem. However, extended post-cycle suppression results in loss
of gains and can result in adverse side effects such as depression
and loss of libido. In contrast, where recovery of natural
testosterone production is rapid, adverse effects on mood or libido
can be reduced or eliminated, and retention of gains can be
excellent. Post-cycle therapy (PCT) with Nolvadex was introduced
specifically to enable faster recovery.
To understand how Nolvadex can speed recovery, it’s important to
understand how inhibition occurs, and how it may be reversed by a
selective estrogen receptor modulator (SERM) such as Nolvadex.
Testosterone production is regulated in a chain process. The testes
produce testosterone according to the amount of LH the pituitary
produces. The pituitary produces LH according to the amount of LHRH
the hypothalamus produces, as well as other factors. And the
hypothalamus produces LHRH according to the current amount of
estrogen and androgen in the blood, as well as other factors.
Off-cycle, estradiol will typically be the most important estrogen
in this process and testosterone the most important androgen, but
in an anabolic steroid cycle, the androgen could be any anabolic
For the moment, we’re going to assume that in an individual
testosterone and estradiol are in a fixed ratio to each other. This
usually is approximately true, because estradiol is produced from
testosterone. When we look at things this way, then we’ll take it
that when testosterone rises or falls, estradiol will rise or fall
In the normal condition - while not using anabolic steroids and
being in good health - this process results in a balance where
testosterone and estradiol remain in the normal range. If briefly
they were to go relatively high for the individual, LHRH and LH
production would decrease, reducing testosterone production and
normalizing the levels.
It’s also the case that if estradiol level is low - or more
precisely is activity at the estrogen receptor is low - the
hypothalamus will produce more LHRH in response. This gives more
LH, and more testosterone.
What happens in an anabolic steroid cycle? Here, the hypothalamus
will always sense abnormally high androgen, and may sense
abnormally high estrogen as well. It therefore shuts down LH
production, so testosterone production shuts down as well.
Again, that’s inevitably going to happen, and in and of itself
doesn’t have to be a problem.
But what about post-cycle? After levels of injected or oral
androgen have dropped, shouldn’t LH production promptly resume?
Androgenic inhibition will have ended.
Unfortunately, often that won’t happen. As mentioned, besides the
current androgen and estrogen levels there are other factors
involved in the regulation of LHRH and LH production. The androgen
and estrogen levels of preceding weeks are important as well. After
the exposures involved in a steroid cycle, androgen and estrogen
levels falling back to normal may not by itself be enough for LH
production to restart, even if estradiol levels are normal.
Now - finally! - is where Nolvadex comes in.
By occupying the binding site of estrogen receptors of a cell
without activating them, Nolvadex prevents these receptors from
being activated by estradiol. The cell then “thinks” that estradiol
levels are very low, and responds accordingly.
In the case of the hypothalamus, it then produces more LHRH in
response to apparently very low estrogen. This stimulates the
pituitary to produce LH, which in turn stimulates the testes,
restoring testosterone production.
There are several proven PCT dosing protocols for Nolvadex.
All of the good protocols first use a higher dose, and then an
ongoing lower dose of 20 mg/day. The reason for this is that when
taking the drug, the amount in one’s system isn’t simply the amount
just taken, but also a buildup of about six days’ worth from
previous dosings. At the start of usage that buildup isn’t there,
and neither will the efficacy unless this is accounted for. If not
accounted for, it takes weeks for levels to build up.
One method of correcting for this is to take a total of 120 mg on
the first day, as three doses of 40 mg. This promptly gets levels
to about the same as would eventually be arrived at with 20 mg/day
dosing. After this, dosing is the standard 20 mg/day.
Another method to quickly obtain proper levels is to use double
dosing for a limited time. I recommend only four days of it, as
that is all that is needed, but many authors recommend two weeks.
(This however overshoots the levels that result from ongoing 20
Dosing should continue until confident that natural testosterone
production has been fully restored. It’s reasonable to plan for 30
days’ use, but more or less may be needed.
Please do realize that using more Nolvadex than the above does not
give better results. Thee is absolutely no reason to use more than
I’ve recommended. Doing so can only worsen side effects.
Side effects even at correct dosing can include vision disturbance
and reduction of libido. If vision disturbance is experienced,
Nolvadex use should be discontinued immediately and an
anti-aromatase such as Arimidex or letrozole should be used
If libido is reduced, the problem is only temporary. On future
occasions, Clomid might be tried as an alternate SERM, because it
can be more favorable in this regard.
There is generally no reason to combine SERMs: for example,
generally Clomid or Nolvadex should be used as the sole SERM,
rather than in combination with each other. However, in some
difficult cases it can be beneficial to use both Clomid and
Nolvadex simultaneously, but at half-doses of each. While at the
hypothalamus there is likely no difference between Clomid alone,
Nolvadex alone, or both together at half dose, at the pituitary
Clomid and Nolvadex work oppositely, so the combination differs
from either alone. (It is from Dr. Scally that I learned the
benefit of combining in some instances.)
Prior to the advent of affordable anti-aromatases, Nolvadex was
also popular as an anti-gynecomastia agent. Today, it’s best to use
an anti-aromatase as a preventative, but if gyno symptoms flare up
during a cycle, immediate treatment with Nolvadex can be helpful.
Dosing for this use is as with PCT.
Tamoxifen citrate is the chemical name of active ingredient in
Nolvadex. Nolvadex is a registered trademark of AstraZeneca UK
Limited in the United States and/or other countries.
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