Nolvadex / Tamoxifen Citrate CAS: 54965-24-1 Anti Estrogen Steroids
Tamoxifen Citrate is the citrate salt of an antineoplastic
nonsteroidal selective estrogen receptor modulator (SERM).
Tamoxifen competitively inhibits the binding of estradiol to
estrogen receptors, thereby preventing the receptor from binding to
the estrogen-response element on DNA. The result is a reduction in
DNA synthesis and cellular response to estrogen. In addition,
tamoxifen up-regulates the production of transforming growth factor
B (TGFb), a factor that inhibits tumor cell growth, and
down-regulates insulin-like growth factor 1 (IGF-1), a factor that
stimulates breast cancer cell growth. Tamoxifen also down-regulates
protein kinase C (PKC) expression in a dose-dependant manner,
inhibiting signal transduction and producing an antiproliferative
effect in tumors such as malignant glioma and other cancers that
Chemical name: Tamoxifen Citrate (Tamoxifen ,Nolvadex,Zitazonium,
CAS NO.: 54965-24-1
Molecular Formula: C26H29NO.C6H8O7
Molecular weight: 563.64
Appearance: white crystalline powder
MP: 140-144 ºC
Storage: Shading, confined preservation
Drug Class: Anabolic Androgenic Steroid
Usage: the goods to anti-estrogen fertility inducer, the objects in
dysfunctional uterine bleeding, polycystic ovary, menstrual
disorders and drug-induced amenorrhea and other gynecologic
diseases;It is used as a first line defense against breast cancer.
Tamoxifen is currently used for the treatment of both early and
advanced estrogen receptor-positive (ER-positive or ER+) breast
cancer in pre- and post-menopausal women. Additionally, it is the
most common hormone treatment for male breast cancer.It is also
approved by the FDA for the prevention of breast cancer in women at
high risk of developing the disease. It has been further approved
for the reduction of contralateral (in the opposite breast) cancer.
The use of tamoxifen is recommended for 10 years.
In 2006, the large STAR clinical study concluded that raloxifene is
equally effective in reducing the incidence of breast cancer, but
after an average 4-year follow-up, although the difference was not
statistically significant, there were 36% fewer uterine cancers and
29% fewer blood clots in women taking raloxifene than in women
Tamoxifen is used to treat infertility in women with anovulatory
disorders. It is given at days 3 to 7 of a woman's cycle.
Tamoxifen improves fertility in males with infertility by
disinhibiting the hypothalamic–pituitary–gonadal axis (HPG axis)
via ER antagonism and thereby increasing the secretion of
luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and
increasing testicular testosterone production.
Tamoxifen is used to prevent or treat gynecomastia.It is taken as a
preventative measure in small doses, or used at the onset of any
symptoms such as nipple soreness or sensitivity. Other drugs are
taken for similar purposes such as clomifene and the anti-aromatase
drugs which are used in order to try to avoid the hormone-related
Occasionally tamoxifen is used in treatment of the rare conditions
of retroperitoneal fibrosis and idiopathic sclerosing mesenteritis.
How to use Tamoxifen CITRATE:
Read the Medication Guide provided by your pharmacist before you
start using tamoxifen and each time you get a refill. If you have
any questions, consult your doctor or pharmacist.
Take this medication by mouth with or without food, usually once or
twice daily for 5 years, or as directed by your doctor. Daily
dosages greater than 20 milligrams are usually divided in half and
taken twice a day, in the morning and evening, or as directed by
your doctor. If you are using the liquid, measure the dose
carefully using a special measuring device/spoon. Do not use a
household spoon because you may not get the correct dose.
Dosage is based on your medical condition and response to therapy.
Use this medication regularly to get the most benefit from it. To
help you remember, take it at the same time(s) each day.
If you have breast cancer that has spread to other parts of the
body, you may experience increased bone/cancer pain and/or disease
flare-up as you start taking tamoxifen. In some cases, this may be
a sign of a good response to the medication. Symptoms include
increased bone pain, increased tumor size, or even new tumors.
These symptoms usually disappear quickly. In any case, report these
symptoms right away to your doctor.
Since this drug can be absorbed through the skin and lungs, women
who are pregnant or who may become pregnant should not handle this
medication or breathe the dust from the tablets. (See also